Such symptoms can be quite troubling to patients, but they need to be balanced against the risk of uncontrolled CNS disease. Some results were surprising. Upon progression, localized disease can sometimes still be treated with local therapy.
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Palbociclib in Treating Patients With Metastatic HER-2 Positive Breast Cancer With Brain Metastasis
This landmark phase 3 trial of adjuvant endocrine therapy offers insights into the care of postmenopausal women with early stage, HR-positive breast cancer. The patient who did well on trastuzumab and who develops brain metastasis can stay on it. The problem with whole-brain radiotherapy is that it can lead to late toxicity, including a decline in cognitive function.
In the future, research may explain why the brain is a common site of disease spread for patients with HER2-positive breast cancer, and offer a means of better treatment, he concluded. J Clin Oncol 29 15 suppl: Studies have consistently demonstrated that the risk of CNS involvement is high in patients with HER2-positive metastatic breast cancer. After completion of study treatment, patients are followed up at 3, 6, her 2 neu cns breast other, and 12 months, and then every 6 months for up to 3 years. Upon progression, localized disease can sometimes still be treated with local therapy.